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This study aimed to determine the clinical and histological characteristics of acitretin-treated patients with atypical psoriasis (AP) and to compare them to the lesions of AP patients not treated with acitretin. The study comprised 23 patients (mean age 57 years) who were diagnosed with AP and treated with acitretin. The clinical and histological characteristics were evaluated in the lesions of AP patients who were treated with acitretin. In the lesions of 17 patients, acitretin produced complete remission. In four patients, acitretin therapy did not induce obvious changes in the clinical aspect of the lesions. In four patients, a concomitant aggravation of the lesions was observed. In contrast, acitretin therapy resulted in complete remission in the lesions of the remaining 18 patients. The mean disease duration was 89 ± 49 months in the patients in complete remission, and there was a significantly longer disease duration in patients with no response to acitretin therapy (102 ± 50 months vs 54 ± 37 months; P = 0.038). Acitretin is a highly effective and relatively safe treatment option for AP. Lesions in patients who were successfully treated with acitretin exhibited a more obvious clinical and histological severity, which may explain the longer disease
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